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KMID : 0359920060250061029
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Korean Journal of Nephrology
2006 Volume.25 No. 6 p.1029 ~ p.1034
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A Case of Classic Polyarteritis Nodosa Presented with Acute Renal Failure
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Park Tae-Woon
Woo Myoung-Lyeol
Han Seo-Goo
Kim Jeong-Hun
Jeon Byung-Soo
Lee Sang-Choel
Yoon Soo-Young
Song Ji-Sun
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Abstract
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Classic polyarteritis nodosa (c-PAN), first described by Kussmaul and Maier in 1866, is a systemic illness characterized by necrotizing inflammation of mediumsized arteries. Rapid progressive renal failure is very rare in c-PAN in contrast to microscopic polyangiitis (MPA). We report a case of c-PAN presented with rapidly progressive renal failure. A 58 year-old male was referred to our hospital for evaluation of asthenia and right visual loss. An increase in serum creatinine level was developed in the 6th day of hospitalization and acute renal failure was aggravated rapidly. Renal biopsy showed the transmural fibrinoid necrosis of small and medium sized arteries with few glomerular crescents. P-ANCA was detected in serum, and all clinical and laboratory findings supported the diagnosis of c-PAN. He was treated with pulse methylprednisolone, followed by oral corticosteroid and cyclophosphamide, and received temporary hemodialysis. After the treatment, he recovered and was discharged but his visual defect was rreversible despite the treatment. (Korean J Nephrol 2006;25(6):1029-1034)
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KEYWORD
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Classic polyarteritis nodosa, Acute renal failure, Anti-neutrophil cytoplasmic antibody
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